Agenesis of the Corpus Callosum

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1. The part of the corpus callosum that develops first 

a. Rostrum

b.Genu

c. Body

d. . Splenium

e. Posterior

 

2. The etiology of agenesis of the corpus callosum is

a. Inflammatory and vascular lesions

b.Teratogens

c. Genetic (autosomal dominant)

d. Genetic (autosomal recessive and sex-linked transmission)

e. All of the above

 

3. Dysgenesis of the corpus callosum 

a. Is also known as partial agenesis

b. Has the caudal portion missing

c. Has the splenium missing

d. Has the body missing

e. All of the above

 

4. All of the following about the findings in agenesis of the corpus callosum are true, except

a. There is significant distortion of the  intracranial architecture 

b.The lateral ventricle has a "tear drop" aspect

c. The frontal horns are usually very enlarged

d. The frontal horns are more separated than normal from the midline

e. The third ventricle is superiorly elongated

 

5. All of the following are central nervous system anomalies associated with agenesis of the corpus callosum, except

a. microcephaly

b. intracranial lipomas

c. interhemispheric cyst

d. Dandy-Walker malformation

e. hyperplasia of the pyramidal tracts

 

6. Which of the following is important in the differential diagnosis for agenesis of the corpus callosum

a. the frontal horn of the lateral ventricle

b. the cavum septum pellucidum

c. the absense of cysts

d. the lack of an interhemispheric fissure

e. the absence of associated anomalies in this entity

 

7. Which of the following is true about the prognosis of the agenesis of the corpus callosum

a. It is dependent upon the cause of the malformation

b. It is lethal

c. A normal development occurs in about 50% of the patients when the agenesis is isolated

d. It depends mainly on The degree of ventricular enlargement

e. There is a well demonstrated association with psychotic disorders

 

8. The diagnosis of agenesis of the corpus callosum

a. Is easier in the first trimester

b. Is very difficult when not performing a targeted examination

c. Is usually made between 16-22 weeks' gestation in rutine ultrasound

d. Is not possible antenatally

e. Is only possible after the 31st week of gestation

 

9. The definitive diagnosis of callosal agenesis depends upon demostration of

a. Increased separation of the hemispheres

b. Upward displacement of the third ventricle

c. Abnormal midline lesions

d. The abscence of the complex formed by the corpus callosum and cavum septum pellucidum

e. The pericallosal artery with doppler ultrasound

 

10. Associated anomalies in agenesis of the corpus callosum

a. Occur in 100% of the cases

b. Are very rare

c. Include chromosomal anomalies in more than 50% of the cases

d. Include tetralogy of Fallot

e. Suggest a local developmental disturbance

 


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