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QUIZ

Neuroblastoma

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1. It is true about neuroblastoma, except:

a. It is an embryonal tumor

b. It is derived from the sympathetic nervous system

c. some are able to produce catecholamines

d. . in about a third of the cases it is localized in the adrenal glands

e. they can be found in the neck or chest

 

2.. According to Evans staging system, a tumor extending in continuity beyond the organ, not crossing the midline, with one homolateral regional lymph node corresponds to:

a. Stage I

b. Stage II

c. Stage III

d. Stage IV

e. Stage IV-S

 

3. It is true about neuroblastomas, except:

a. It is most frequently cystic

b. It is usually right-sided

c. It is usually identified in the third trimester by ultrasound

d. It is more common than subdiaphragmatic extralobar pulmonary sequestrations

e. It can give metastases to liver, skin or bone marrow

 

4. According to Kramer et al neuroblastoma can be associated with

a. sex hormone exposure 3 months prior to pregnancy

b. frequent alcohol consumption

c. materal use of diuretic drugs

d. all of the above

e. none of the above

 

5. More favorable outcome is associated with:

a.undifferentiated tumors

b. mostly adrenal tumors

c. high stage tumors

d. tumors in which gene markers of eary fetal ganglionic lineage are expressed

e. extra-adrenal location

 

6. The reference for median concentration of neuron-specific enolase in cord blood is

a. 4.8 micrograms

b. 8.0 micrograms

c. 16.8 micrograms

d. 19.4 micrograms

e. 1.8 mg

 

7. A very characteristic sonographic finding in the neuroblastoma is:

a. its complex appearence

b. it is always purely cystic and located in the neck

c. its paravertebral intra-abdominal location

d. the anterior displacement of the vena cava

e. the associated hydronephrosis

 

8. The incidence of neuroblastoma is about:

a. 1 to 3 in 10,000 live births M1:F1

b. 0.3 to 1 in 1,000 live births M2:F1

c. 0.3 to 1 in 10,000 live births M1:F1

d. 0.3 to 1 in 1,000 live births M1:F2

e. 1 to 3 in 10,000 live births M2:F1

 

9. Are differential diagnoses for neuroblastoma, except:

a. duplex anomalies of the kidney

b.solid Wilm's tumor

c. cystic adenomatoid malformation

d. .pulmonary sequestration

e. lymphangioma

 

10. It can establish the aggressiveness of neuroblastoma

a. neuropeptide Y

b. lack of phenylethanolamine N-methyltransferase expression

c. growth-associated protein-43

d. Bcl-2

e. the amplification of the N-myc gene


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